qoxD [2017-04-24 15:34:12]

cytochrome aa3 quinol oxidase (subunit IV)

locus: BSU38140

pI: 5.94

mw: 13.55 kDa

protein length: 124 aa

gene length: 372 bp

function: respiration

product: cytochrome aa3 quinol oxidase (subunit IV)

essential: no

ec: 1.10.3.-

synonyms: ipa-40d

Genomic Context

categories

• [category|SW 2|Metabolism] → [category|SW 2.1|Electron transport and ATP synthesis] → [category|SW 2.1.2|Respiration] → [category|SW 2.1.2.1|Terminal oxidases]
• [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]

This gene is a member of the following [SW|regulons]

• [SW|stringent response], [SW|CitB regulon] (putative)

Gene

Coordinates: 3,914,315 → 3,914,689

The protein

Catalyzed reaction/ biological activity

• Ubiquinol-8 O₂ = Ubiquinone-8 H₂O (according to Swiss-Prot)

Protein family

• cytochrome c oxidase bacterial subunit 4 family (according to Swiss-Prot)

[SW|Localization]

• cell membrane (according to Swiss-Prot)

Expression and Regulation

Operons

• genes: [gene|48A9E1E39838BFFCF12CADF0A8D8E6FFDCA6F175|qoxA]-[gene|CBF2DCFFD8195304F942ECBA8596444F0AC47CC6|qoxB]-[gene|CD4520EF427AEFDCF028AE063BC373FA6DCE379E|qoxC]-[gene|03335DC50CED7B38E2380640AE108ADA09A2CBDF|qoxD]
  description: [Pubmed|1316894]

  regulatory mechanism

  • [regulon|stringent response|stringent response]: negative regulation, in [regulon|stringent response|stringent response]
  • [protein|E15E9F88B0E03FE8834C646369D2F4B4E713EF41|CitB]: mRNA binding, in [regulon|E15E9F88B0E03FE8834C646369D2F4B4E713EF41|CitB regulon]

  regulation

  • [protein|search|RelA] dependent downregulation (Class I) during stringent response [Pubmed|11948165]

  additional information

  • the presence of an iron-responsive element bound by [SW|CitB] between ''[SW|feuA]'' and ''[SW|feuB]'' suggests iron-dependent regulation by [SW|CitB] [Pubmed|10468622]

References

• 11073895,1316894,20351111,10551842,10468622